Ototoxicity and Noise

INF-α and Ototoxicity

INTRODUCTION INF- α is a common drug for the treatment of hepatitis B and C. Although a variety of related complications are discussed, possible ototoxic effects of this mediation are not well described. METHODS AND MATERIALS In a before-after control study, 24 patients who received INF- α for the treatment of hepatitis B and C and 30 normal controls were included. Subjective and objective ot...

Ototoxicity: Old and New Foes

Drug-induced ototoxicity has been known for centuries. Already in the seventeenth century, hearing loss was described to be a side effect of quinine. The postWorld War II pharmaceutical industry boomed with the production of aminoglycoside antibiotics followed by diuretics and cytostatic drugs. Wide-spread and long-term usage of these medications brought the knowledge about their unwanted ototo...

[Lack of protection against gentamicin ototoxicity by auditory conditioning with noise].

INTRODUCTION Auditory conditioning consists of the pre-exposure to low levels of a potential harmful agent to protect against a subsequent harmful exposure. OBJECTIVE To confirm if conditioning with an agent different from that used to cause the trauma can also be effective. METHODS This was an experimental study with 17 guinea pigs, divided into three groups: an ototoxic control group (Con...

Objective Measures of Ototoxicity

A leading cause of preventable sensorineural hearing loss is therapeutic treatment with medications that are toxic to inner ear tissues, including certain drugs used to fight cancer and life-threatening infectious diseases. Ototoxic-induced hearing loss typically begins in the high frequencies and progresses to lower frequencies as drug administration continues (Campbell & Durrant, 1993; Campbe...

Ototoxicity: Current Issues.